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The important cellular functions they participate in include sensing membrane curvature, formation of tubular or spherical membrane intermediates, protecting membranes and lipid droplets, promoting membrane anchorage, and mediating membrane fission or scaffolding signalling components [38,39,40,41,42]

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Another MTHFR variant, an A-to-C change at position 1298, has also been associated with reduced MTHFR activity and increased NTD risk in some (46, 47), but not all (48), populations